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Principal Scientist, Genomic Translational Research

We are seeking a highly motivated Principal Scientist with hands-on expertise in molecular biology in the context of immuno-oncology to join the Oncology Translational Research team within GSK Oncology TA. The successful candidate will work as part of a team that evaluates patient-derived organoids through cutting-edge cellular, genomic and molecular techniques, and partners with AI/ML and analytics experts to integrate data from these multimodal approaches to generate clinical insights. The goal of this is to improve cancer patient risk stratification, identify clinical biomarkers and predict future targeted and/or immuno-therapy susceptibilities.

In this role you will:

• Create protocols and perform the sample processing for genomic experiments (e.g. RNAseq, WES, scRNAseq).
• Prepare samples and libraries for sequencing.
• Run flow cytometry and FACS sorting experiments.
• Develop immunogenicity assays for product validation.
• Offer technical expertise and support to other team members, helping them troubleshoot and optimize their experimental protocols. Solve technical issues operate as part of a cross-functional project team.
• Collaborate with King's College London scientists within the GSK-KCL Translational Oncology Research Hub, an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

Why you?

Basic Qualifications & Skills

We are looking for professionals with these required skills to achieve our goals:

• PhD (or equivalent experience) in Cancer Biology, Genomics, Immunology, or related field, with extensive experience in cancer genomics.

• Expertise with NGS, flow cytometry, single cell RNA sequencing and library preparation.

• Strong background in developing and applying cutting-edge genomic technologies to study cancer biology.
• Strong understanding of immunology and cancer biology, including T cell biology and the molecular mechanisms underlying tumorigenesis and cancer progression.
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units.
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• A track record of scientific publication.
• Experience in collaboration with biopharma.
• Strong strategic thinking and problem-solving skills, with the ability to navigate complex scientific and business challenges.
• Experience in analysis of major next-generation sequencing (sc TCR) techniques and generation of insights from such data.

Closing Date for Applications – 9th March 2026

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.

Find out more:

Our approach to R&D.

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Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the Link where you will find answers to multiple questions we receive

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